Dr Omar Salem
Computational Biologist at Roche (formally: Hoffmann-La Roche AG)
Dr Omar Salem
Dr Omar Salem
About
Salem is a computational biologist at Roche. He holds a PhD in Medical Sciences from McMaster University.
Current research
Salem uses single cell technologies and various machine learning tools to study changes in immune cells in the context of different pathologies with the aim to identify novel diagnostic biomarkers as well as druggable targets for treating different conditions.
Future research vision
Key publications

El-Sayes, N et al. A Combination of Chemotherapy and Oncolytic Virotherapy Sensitizes Colorectal Adenocarcinoma to Immune Checkpoint Inhibitors in a cDC1-Dependent Manner. International Journal of Molecular Sciences, 2022.

Vito, A et al. Immune Checkpoint Blockade in Triple Negative Breast Cancer Influenced by B cells through Myeloid-Derived Suppressor Cells. Communications Biology, 2021.

Vito, A et al. Response to FEC Chemotherapy and Oncolytic HSV-1 Is Associated with Macrophage Polarization and Increased Expression of S100A8/A9 in Triple Negative Breast Cancer. Cancers, 2021.

Salem, O et al. The highly Expressed 5’isomiR of hsa-miR-140-3p Contributes to the Tumor-Suppressive Effects of miR-140 by Reducing Breast Cancer Proliferation and Migration. BMC Genomics, 2016.

Bridle, B et al. Privileged Antigen Presentation in Splenic B Cell Follicles Maximizes T Cell Responses in Prime-Boost Vaccination. Journal of Immunology, 2016.

Key awards

Ontario Graduate Scholarship, Ministry of Training, Colleges and Universities (Canada).

PhD Graduate Scholarship, McMaster University.

MSc Scholarship, Helmholtz International Graduate school (HIGS).

Scholarship, Deutscher Akademischer Austauschdienst (DAAD).

Gerhard Schröder Award, German University in Cairo.

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